It's something he's done in the pages of the aforementioned Generations, Doom Patrol, Alpha Flight - all with young women (and I'm saying this to be polite) "Falling in love with and winning the hearts of" older men - and that hot mess Marvel:The Lost Generation, where the genders were, for once, reversed.
Most famous of all of them, though, is from the pages of Byrne's run on The Fantastic Four. Reed is in college, Sue is twelve.
Weirder than Byrne's repeated trips to this creepy-ass ol' well has been the general reaction of comic fandom, or the lack thereof. Byrne's ardent fans defend the creative choices, naturally, and those largely disinterested in the fella's work tend to stop just shy of calling in Detective Munch. I never thought, though, I'd find anyone who'd be angry if Byrne's tendency to craft relationships between older men and younger - often legally underage - women were removed from canon.
In the latest issue of Fantastic Four:
"...and the new one certainly isn't an improvement..." he says, meaning "The one without the implied statutory rape".
Tom Brevoort - whom I get to admire more every day for everything except his fashion sense (which Little Rascal did you mug for that hat, Tom?) - warmed my heart by happily, if carefully, throwing John Byrne under a bus.
"...that sequence struck the both of us, in 21st century terms, as being more than a little bit creepy."